![]() ![]() Based on the presence or absence of these factors we will assign a risk profile to each patient In addition we will investigate personalized prophylaxis based on genetic and acquired risk factors.Ī randomized controlled trial comparing a policy with the anticoagulant LMWH to a policy with no anticoagulant in patients with lower leg cast immobilization.ĭetermination of genetic and acquired risk factors will be performed at the start of the study. treatment with low molecular weight heparin (LMWH) during lower leg plaster cast immobilization following surgical or conservative treatment. Lastly, we will determine high risk groups that will benefit most from anticoagulant treatment.Ĭomparative effectiveness research to determine cost-effectiveness of an existing healthcare policy, i.e. Furthermore we will follow subjects with an adverse event for a longer period, during which we will assess the long term sequelae of these events. In the proposed study we will use relevant symptomatic endpoints in a large cohort of patients. From these trials an overall risk benefit-balance could not be established, hence the current controversy exists. Trials that have been carried out were aimed at efficacy only, had small sample sizes and therefore mainly used asymptomatic thrombosis as endpoint. Condition or diseaseĭeep Venous Thrombosis Pulmonary EmbolismĬurrently, guidelines and clinical practice differ considerably with respect to use of anticoagulant treatment during cast immobilization of the lower leg. In addition the investigators will investigate personalized prophylaxis based on genetic and acquired risk factors. Objective: Comparative effectiveness research to determine cost-effectiveness of two existing policies, i.e. Lastly, the investigators will determine high risk groups that will benefit most from anticoagulant treatment. Furthermore the investigators will follow subjects with an adverse event for a longer period, during which the investigators will assess the long term sequelae of these events. In the proposed study the investigators will use relevant symptomatic endpoints in a large cohort of patients. ![]() From these trials an overall risk benefit-balance could not be established, hence the current controversy. Why Should I Register and Submit Results?Ĭurrently, guidelines and clinical practice differ considerably with respect to use of anticoagulant treatment during cast immobilization of the lower leg. ![]()
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